:root {
  --navy: #2b3e50;
  --blue: #4a6572;
  --blue-dark: #34495e;
  --red: #e74c3c;
  --ink: #333;
  --muted: #5f6870;
  --line: #d5dadd;
  --soft: #fff;
  --surface: #fff;
  font-family: Arial, Helvetica, sans-serif;
  color: var(--ink);
  background: var(--soft);
  font-synthesis: none;
  text-rendering: optimizeLegibility;
}
* { box-sizing: border-box; }
html { scroll-behavior: smooth; scroll-padding-top: 24px; }
body { margin: 0; font-size: 15px; line-height: 1.65; }
a { color: var(--blue-dark); text-decoration: none; }
a:hover { text-decoration: underline; text-underline-offset: 3px; }
button, input, select { font: inherit; }
button { cursor: pointer; }
button:disabled { cursor: default; }
button:focus-visible, a:focus-visible, input:focus-visible, select:focus-visible, [tabindex="0"]:focus-visible { outline: 2px solid #365b73; outline-offset: 3px; }
img { max-width: 100%; height: auto; }
img[hidden] { display: none; }
h1, h2, h3, p, figure { margin: 0; }
h1, h2, h3 { line-height: 1.3; color: var(--navy); }
h1 { font-size: 34px; font-weight: 600; }
h2 { font-size: 25px; font-weight: 600; }
h3 { font-size: 17px; font-weight: 600; }
p + p { margin-top: 12px; }
main:focus { outline: none; }
.page-width { width: min(1200px, calc(100% - 64px)); margin-inline: auto; }
.section-space { padding-block: 38px; }
.section-bottom { padding-bottom: 50px; }
.soft-section { background: #fff; border-block: 1px solid var(--line); }
.eyebrow { color: var(--muted); font-size: 11px; font-weight: 600; letter-spacing: .07em; margin-bottom: 9px; }
.small-label { display: block; color: var(--muted); font-size: 12px; font-weight: 600; }
.visually-hidden { position: absolute; width: 1px; height: 1px; padding: 0; margin: -1px; overflow: hidden; clip: rect(0, 0, 0, 0); white-space: nowrap; border: 0; }
.skip-link { position: fixed; z-index: 100; left: 16px; top: -100px; background: #fff; color: var(--navy); padding: 10px 18px; border: 2px solid var(--navy); }
.skip-link:focus { top: 10px; }
.site-header { background: var(--navy); color: #fff; }
.header-inner { width: min(1200px, calc(100% - 64px)); margin: auto; min-height: 82px; display: flex; align-items: center; gap: 28px; }
.brand { display: inline-block; font-size: 29px; font-weight: 700; letter-spacing: .02em; color: #fff; line-height: 1.2; white-space: nowrap; }
.brand:hover { text-decoration: none; }
.header-caption { border-left: 1px solid #7a8995; padding-left: 28px; color: #e3e8eb; font-size: 15px; }
.nav-bar { background: var(--blue); }
.primary-nav { width: min(1200px, calc(100% - 64px)); margin: auto; display: flex; align-items: stretch; }
.primary-nav a { color: #fff; font-size: 14px; padding: 12px 23px 10px; border-bottom: 3px solid transparent; white-space: nowrap; }
.primary-nav a:first-child { margin-left: -23px; }
.primary-nav a:hover { text-decoration: none; background: var(--blue-dark); }
.primary-nav a[aria-current="page"] { background: var(--blue-dark); border-bottom-color: var(--red); }
.site-header a:focus-visible, .site-footer a:focus-visible { outline-color: #fff; }
.hero { background: #fff; border-bottom: 1px solid var(--line); padding: 34px 0 30px; }
.hero h1 { font-size: 38px; margin-bottom: 10px; }
.hero-subtitle { font: 25px/1.4 Georgia, "Times New Roman", serif; color: var(--navy); max-width: 1000px; }
.hero-description { max-width: 1060px; font-size: 14px; color: var(--ink); line-height: 1.85; margin-top: 18px; }
.button-row { display: flex; align-items: center; flex-wrap: wrap; gap: 22px; margin-top: 22px; }
.button { display: inline-flex; align-items: center; justify-content: center; gap: 13px; min-height: 38px; padding: 8px 15px; border: 1px solid transparent; border-radius: 3px; font-size: 13px; font-weight: 500; line-height: 1.5; text-align: center; text-decoration: none; }
.button:hover { text-decoration: none; }
.button-primary { color: #fff; background: var(--blue); border-color: var(--blue); }
.button-primary:hover { background: var(--blue-dark); border-color: var(--blue-dark); }
.button-primary:disabled { opacity: .65; }
.button-secondary { color: var(--blue-dark); background: #fff; border-color: #aebbc2; }
.button-secondary:hover { border-color: var(--blue); text-decoration: underline; }
.text-link { font-size: 13px; text-decoration: underline; text-underline-offset: 3px; }
.text-link span { margin-left: 6px; }
.hero-stats { display: inline-flex; align-items: stretch; gap: 0; padding-top: 18px; margin-top: 24px; border-top: 1px solid var(--line); }
.hero-stats div { padding: 0 25px; border-right: 1px solid var(--line); display: flex; flex-direction: column; }
.hero-stats div:first-child { padding-left: 0; }
.hero-stats div:last-child { border: 0; padding-right: 0; }
.hero-stats strong { color: var(--navy); font-size: 23px; font-weight: 600; line-height: 1.2; }
.hero-stats span { font-size: 11px; color: var(--muted); margin-top: 5px; }
.hero-figure { border: 1px solid var(--line); background: #fff; margin-bottom: 24px; }
.figure-label { padding: 9px 15px; border-bottom: 1px solid var(--line); color: var(--navy); font-size: 13px; font-weight: 600; background: #fff; }
.hero-figure img { display: block; width: 100%; padding: 22px 35px; }
.hero-figure figcaption { padding: 11px 15px; border-top: 1px solid var(--line); font-size: 12px; line-height: 1.7; color: var(--muted); }
.hero-figure figcaption strong { color: var(--ink); }
.hero-figure figcaption a, .scientific-figure figcaption a { margin-left: 8px; text-decoration: underline; white-space: nowrap; }
.publication-strip { display: flex; align-items: baseline; gap: 20px; background: #fff; border-left: 3px solid var(--blue); padding: 15px 20px; margin-top: 24px; font-size: 12px; line-height: 1.8; }
.publication-strip > strong { font-size: 12px; color: var(--navy); }
.publication-strip cite { font-style: normal; }
.publication-strip a { text-decoration: underline; white-space: nowrap; }
.publication-strip .publication-title { white-space: normal; }
.publication-strip p span { color: var(--muted); }
.section-heading { display: flex; align-items: baseline; justify-content: space-between; gap: 38px; padding-bottom: 12px; border-bottom: 1px solid #bbc5cc; margin-bottom: 22px; }
.section-heading > p { color: var(--muted); font-size: 13px; max-width: 440px; }
.resource-grid { display: grid; grid-template-columns: repeat(4, 1fr); gap: 18px; }
.resource-card { display: flex; flex-direction: column; border: 1px solid #bdc8ce; border-top: 3px solid var(--blue); background: #fff; padding: 19px 20px 14px; color: var(--ink); }
.resource-card:hover { text-decoration: none; border-color: var(--blue); }
.resource-card h3 { font-size: 20px; }
.resource-card p { flex: 1; font-size: 13px; line-height: 1.75; margin-top: 9px; min-height: 46px; color: var(--muted); }
.card-bottom { display: flex; justify-content: space-between; gap: 12px; padding-top: 11px; border-top: 1px solid var(--line); margin-top: 15px; font-size: 12px; color: var(--muted); }
.card-bottom > span { color: var(--blue-dark); text-decoration: underline; text-underline-offset: 3px; }
.steps-grid { display: grid; grid-template-columns: repeat(3, 1fr); gap: 30px; }
.step-card { border-left: 2px solid #b9c6ce; padding-left: 17px; }
.step-number { display: block; font-size: 12px; color: var(--blue); margin-bottom: 6px; font-weight: 600; }
.step-card h3 { font-size: 16px; margin-bottom: 9px; }
.step-card p { font-size: 13px; line-height: 1.85; }
.figure-key { font-size: 12px; color: var(--muted); line-height: 1.8; margin-top: 21px; }
.feature-grid { display: grid; gap: 24px; align-items: start; }
.section-intro { font-size: 15px; margin-top: 15px; line-height: 1.7; }
.feature-point { display: flex; gap: 15px; margin-top: 19px; }
.feature-point > span { font-size: 12px; color: var(--blue); font-weight: 600; margin-top: 2px; }
.feature-point h3 { font-size: 15px; margin-bottom: 6px; }
.feature-point p { font-size: 13px; line-height: 1.85; }
.scientific-figure { border: 1px solid var(--line); background: #fff; }
.scientific-figure img { display: block; width: 100%; padding: 20px; }
.scientific-figure figcaption { border-top: 1px solid var(--line); padding: 12px 16px; font-size: 12px; color: var(--muted); line-height: 1.8; }
.scientific-figure figcaption strong { color: var(--ink); }
.overview-figure img { padding: 24px 35px; }
.allocation-grid { display: grid; grid-template-columns: repeat(3, 1fr); gap: 30px; margin-top: 22px; }
.allocation-grid > div { padding-left: 16px; border-left: 2px solid #b9c6ce; }
.allocation-grid h3 { font-size: 16px; margin-top: 5px; }
.allocation-grid p { font-size: 13px; margin-top: 8px; line-height: 1.8; }
.guidance-panel { display: grid; grid-template-columns: .7fr 1.8fr; gap: 35px; border: 1px solid var(--line); border-left: 3px solid var(--blue); background: #fff; padding: 26px; }
.guidance-panel > div > p:last-child { font-size: 13px; color: var(--muted); margin-top: 12px; }
.guidance-panel ol { margin: 0; padding-left: 18px; font-size: 13px; }
.guidance-panel li { padding-left: 6px; line-height: 1.85; }
.guidance-panel li + li { margin-top: 12px; }
.highlight { font-weight: bold; color: #e74c3c; }
.site-footer { color: #fff; background: var(--navy); padding: 25px 0 18px; }
.footer-inner, .footer-bottom { width: min(1200px, calc(100% - 64px)); margin-inline: auto; }
.footer-inner { display: flex; align-items: center; gap: 25px; }
.brand-small { font-size: 21px; }
.footer-inner p { color: #d1dbe0; font-size: 12px; }
.footer-inner > a:last-child { margin-left: auto; font-size: 13px; color: #fff; }
.footer-bottom { font-size: 11px; color: #d1dbe0; margin-top: 19px; padding-top: 15px; border-top: 1px solid #6b7b88; }
.page-heading { padding-top: 28px; padding-bottom: 26px; }
.page-heading h1 { font-size: 32px; }
.page-description { font-size: 14px; max-width: 850px; line-height: 1.85; margin-top: 12px; }
.breadcrumb { display: inline-flex; align-items: center; gap: 12px; font-size: 12px; color: var(--muted); margin-bottom: 17px; }
.breadcrumb span { color: var(--muted); }
.compact-heading { padding-bottom: 23px; }
.catalog-panel { background: #fff; border: 1px solid #c4cdd3; }
.catalog-toolbar { display: flex; align-items: center; justify-content: space-between; gap: 20px; padding: 20px 22px 15px; }
.search-form { position: relative; display: flex; align-items: center; gap: 9px; width: min(540px, 100%); }
.search-form input { min-width: 0; width: 100%; height: 40px; border: 1px solid #aebbc2; border-radius: 3px; padding: 9px 13px 9px 37px; color: var(--ink); background: #fff; font-size: 13px; }
.search-form input::placeholder { color: var(--muted); }
.search-form .button { min-height: 40px; padding-inline: 20px; }
.search-icon { position: absolute; left: 14px; width: 12px; height: 12px; border: 1.5px solid #647682; border-radius: 50%; pointer-events: none; }
.search-icon::after { position: absolute; content: ""; width: 5px; height: 1.5px; right: -4px; bottom: -3px; transform: rotate(45deg); background: #647682; }
.download-catalog { white-space: nowrap; font-size: 12px; }
.catalog-meta { display: flex; justify-content: space-between; align-items: center; gap: 18px; padding: 0 22px 16px; }
.catalog-meta p { margin: 0; font-size: 12px; color: var(--muted); }
.catalog-meta #rowCount { font-weight: 600; }
.table-scroll { overflow-x: auto; min-height: 145px; }
table { border-collapse: collapse; width: 100%; text-align: left; font-size: 13px; }
th { color: #fff; background: var(--blue); border-top: 1px solid var(--blue); border-bottom: 1px solid var(--blue-dark); font-weight: 500; }
th:first-child, td:first-child { padding-left: 22px; }
th:last-child, td:last-child { padding-right: 22px; }
.sort-button { display: inline-flex; align-items: center; gap: 7px; padding: 12px 14px 12px 0; border: 0; background: transparent; color: inherit; font-size: 12px; line-height: 1.5; font-weight: 500; text-align: left; }
.sort-button:hover { text-decoration: underline; text-underline-offset: 3px; }
.sort-button:focus-visible { outline-color: #fff; }
.sort-indicator { font-size: 13px; opacity: .8; }
.column-unit { font-size: 11px; font-weight: 400; }
th[aria-sort="ascending"] .sort-indicator, th[aria-sort="descending"] .sort-indicator { opacity: 1; font-weight: 700; }
td { padding: 11px 14px 11px 0; border-bottom: 1px solid #dfe3e6; max-width: 300px; overflow-wrap: anywhere; line-height: 1.65; vertical-align: middle; }
tbody tr { background: #fff; }
tbody tr:last-child td { border-bottom: 0; }
.record-link { color: var(--blue-dark); text-decoration: underline; font-weight: 600; text-underline-offset: 3px; }
.transcript-cell { font-size: 12px; color: var(--muted); white-space: nowrap; font-variant-numeric: tabular-nums; }
.numeric-cell { font-variant-numeric: tabular-nums; }
.badge { display: inline-block; padding: 2px 7px; border: 1px solid #c8d3d9; border-radius: 2px; font-size: 12px; line-height: 1.5; white-space: normal; font-weight: 400; }
.badge-verified { color: #344f60; background: #fff; }
.state-cell { padding: 40px 22px !important; text-align: center; color: var(--muted); max-width: none; }
.state-cell strong { display: block; font-size: 15px; color: var(--navy); }
.state-cell p { font-size: 13px; margin-top: 8px; }
.state-cell .button { margin-top: 17px; }
.catalog-footer { display: flex; align-items: center; justify-content: space-between; gap: 18px; padding: 14px 22px; border-top: 1px solid var(--line); background: #fff; }
.catalog-footer label { display: flex; align-items: center; gap: 10px; font-size: 12px; color: var(--muted); white-space: nowrap; }
.catalog-footer select { font-size: 12px; border: 1px solid #afbbc2; background: #fff; color: var(--ink); border-radius: 2px; padding: 3px 6px; }
.pagination { display: flex; align-items: center; gap: 5px; }
.pagination button { min-width: 30px; height: 30px; border: 1px solid #b7c2c9; border-radius: 2px; color: var(--blue-dark); background: #fff; font-size: 12px; line-height: 1; }
.pagination button:hover { border-color: var(--blue); text-decoration: underline; }
.pagination button[aria-current="page"] { background: var(--blue); color: #fff; border-color: var(--blue); }
.pagination-gap { padding: 0 3px; color: var(--muted); font-size: 12px; }
.catalog-note { margin-top: 18px; color: var(--muted); font-size: 12px; line-height: 1.85; }
.catalog-note a { text-decoration: underline; }
.notice { padding: 17px; border: 1px solid var(--line); background: #fff; margin-top: 18px; font-size: 13px; }
.about-layout { display: grid; grid-template-columns: 1.9fr 1fr; gap: 26px; align-items: start; }
.content-panel { padding: 25px; border: 1px solid var(--line); background: #fff; scroll-margin-top: 20px; }
.content-panel > h2 { font-size: 24px; margin-bottom: 19px; }
.content-prose { font-size: 14px; line-height: 1.9; }
.content-prose h2 { margin-bottom: 18px; }
.content-prose p + p, .content-prose p + ol, .content-prose ol + p { margin-top: 14px; }
.content-prose ol { padding-left: 24px; }
.content-prose li { padding-left: 3px; }
.content-prose li + li { margin-top: 9px; }
.content-panel > p { font-size: 14px; line-height: 1.9; }
.content-panel .scientific-figure { margin-top: 22px; }
.contact-panel { padding: 25px; background: #fff; border: 1px solid var(--line); border-top: 3px solid var(--blue); }
.contact-panel h2 { font-size: 23px; }
.contact-panel > p:not(.eyebrow) { font-size: 14px; margin-top: 15px; }
.contact-email { display: flex; justify-content: space-between; gap: 10px; font-size: 15px; font-weight: 600; margin-top: 16px; overflow-wrap: anywhere; text-decoration: underline; }
.aside-divider { height: 1px; background: var(--line); margin-block: 24px; }
.contact-panel h3 { font-size: 16px; margin-bottom: 13px; }
.aside-link { display: flex; justify-content: space-between; font-size: 14px; padding: 6px 0; }
.publication-card { border-top: 2px solid var(--blue); padding-top: 20px; margin-top: 25px; }
.publication-card h3 { font: 18px/1.55 Georgia, "Times New Roman", serif; }
.publication-card p:not(.eyebrow) { font-size: 13px; color: var(--muted); margin-top: 10px; }
.publication-card > a { display: inline-block; margin-top: 10px; font-size: 13px; text-decoration: underline; }
.detail-heading { padding-bottom: 25px; }
.detail-title-row { display: flex; align-items: center; justify-content: space-between; gap: 25px; }
.detail-title-row h1 { font-size: 34px; }
.record-stats { display: flex; gap: 0; padding: 19px 0; margin: 23px 0 0; border-block: 1px solid #bcc6cc; }
.record-stats > div { padding: 0 32px; border-right: 1px solid #c8d0d5; }
.record-stats > div:first-child { padding-left: 0; }
.record-stats > div:last-child { border: 0; }
.record-stats dt { color: var(--muted); font-size: 12px; margin-bottom: 6px; }
.record-stats dd { margin: 0; font-size: 18px; line-height: 1.5; color: var(--navy); font-weight: 500; }
.record-stats dd > span:not(.badge) { font-size: 12px; color: var(--muted); }
.record-stats .transcript-id { font-size: 14px; padding-top: 2px; }
.detail-layout { display: grid; grid-template-columns: minmax(0, 1fr) 255px; gap: 26px; align-items: start; }
.detail-main { display: grid; grid-template-columns: minmax(0, 1fr); gap: 20px; min-width: 0; }
.detail-main > .content-panel { min-width: 0; }
.panel-heading { display: flex; align-items: baseline; gap: 12px; padding-bottom: 11px; margin-bottom: 17px; border-bottom: 1px solid #bcc6cc; }
.panel-heading h2 { font-size: 22px; }
.section-index { font-size: 12px; color: var(--blue); }
.preserve-lines { white-space: pre-line; overflow-wrap: anywhere; }
.source-note { font-size: 12px !important; color: var(--muted); margin-top: 16px; }
.subsection-title { margin-top: 22px; font-size: 17px; }
.references { padding-left: 20px; font-size: 13px; line-height: 1.85; margin: 13px 0 0; overflow-wrap: anywhere; }
.references li + li { margin-top: 10px; }
.download-panel { display: flex; flex-wrap: wrap; align-items: center; justify-content: space-between; gap: 20px; padding: 17px; border: 1px solid #c7d0d6; background: #fff; margin-top: 22px; }
.download-panel > * { min-width: 0; max-width: 100%; }
.download-panel h3 { font-size: 14px; }
.download-panel p { font-size: 12px; color: var(--muted); overflow-wrap: anywhere; margin-top: 5px; }
.download-panel .button { font-size: 12px; white-space: nowrap; }
.download-panel .resource-unavailable { color: #9b362b; max-width: 230px; }
.section-description { font-size: 13px !important; margin-bottom: 19px; }
.plasmid-list { display: grid; }
.plasmid-card { padding: 17px 0; border-bottom: 1px solid var(--line); }
.plasmid-card:first-child { padding-top: 0; }
.plasmid-card:last-child { padding-bottom: 0; border-bottom: 0; }
.plasmid-card h3 { font-size: 15px; line-height: 1.6; overflow-wrap: anywhere; }
.repository-links { display: flex; flex-wrap: wrap; gap: 12px 30px; margin: 13px 0 0; }
.repository-links dt { font-size: 12px; color: var(--muted); margin-bottom: 3px; }
.repository-links dd { margin: 0; font-size: 13px; }
.repository-links a { text-decoration: underline; }
.evidence-figure { border: 1px solid var(--line); margin-top: 20px; }
.evidence-figure figcaption { display: flex; align-items: baseline; justify-content: space-between; gap: 16px; background: #fff; border-bottom: 1px solid var(--line); padding: 11px 14px; font-size: 13px; }
.evidence-figure figcaption strong { font-weight: 500; color: var(--navy); }
.evidence-figure figcaption > a { font-size: 12px; white-space: nowrap; text-decoration: underline; }
.evidence-image { display: block; width: 100%; padding: 16px; }
.wb-grid { display: grid; grid-template-columns: repeat(2, minmax(0, 1fr)); align-items: start; gap: 18px; margin-top: 20px; }
.wb-grid > .evidence-figure { min-width: 0; margin-top: 0; }
.wb-grid > .evidence-figure:only-child { grid-column: 1 / -1; width: 100%; max-width: 680px; justify-self: center; }
.wb-grid .evidence-figure figcaption { flex-wrap: wrap; gap: 7px 12px; }
.wb-grid .evidence-image { width: auto; max-width: 100%; height: auto; max-height: 640px; margin-inline: auto; object-fit: contain; }
.asset-placeholder { padding: 30px 20px; text-align: center; background: #fff; color: var(--muted); font-size: 13px; }
.asset-placeholder strong { color: #9b362b; font-size: 14px; font-weight: 500; }
.asset-placeholder p { margin-top: 7px; font-size: 13px; }
.asset-placeholder .button { margin-top: 16px; }
.empty-note { font-size: 13px; color: var(--muted); padding-block: 6px; }
.detail-sidebar { min-width: 0; position: sticky; top: 20px; display: grid; gap: 20px; }
.sidebar-panel { border: 1px solid var(--line); background: #fff; padding: 21px; }
.sidebar-panel .eyebrow { padding-bottom: 10px; margin-bottom: 10px; border-bottom: 1px solid var(--line); font-size: 11px; }
.section-nav { display: grid; gap: 4px; }
.section-nav a { display: flex; align-items: center; justify-content: space-between; gap: 10px; font-size: 13px; padding: 6px 0; }
.section-nav a span { font-size: 11px; color: var(--muted); }
.database-links { display: grid; gap: 16px; overflow-wrap: anywhere; }
.database-links .small-label { font-size: 11px; font-weight: 400; margin-bottom: 4px; }
.database-links a, .database-links > div > span:last-child { font-size: 13px; }
.database-links a { text-decoration: underline; }
.sidebar-note { border: 1px solid var(--line); border-left: 3px solid var(--blue); padding: 20px; background: #fff; }
.sidebar-note h3 { font-size: 14px; }
.sidebar-note p { font-size: 12px; color: var(--muted); line-height: 1.85; margin-top: 11px; }
.sidebar-note a { display: block; font-size: 12px; text-decoration: underline; margin-top: 14px; }
.not-found { max-width: 650px; margin: 30px auto 70px; text-align: center; }
.not-found p:not(.eyebrow) { margin-top: 18px; color: var(--muted); }
.not-found .button { margin-top: 23px; }
.not-found .button-row { justify-content: center; }
@media (max-width: 1100px) {
  .resource-grid { grid-template-columns: repeat(2, 1fr); }
  .hero-subtitle { font-size: 22px; }
  .hero-stats div { padding-inline: 18px; }
  .hero-stats span { font-size: 10px; }
  .hero-description { font-size: 13px; }
  .feature-grid { gap: 28px; }
  .section-heading > p { max-width: 350px; }
  .resource-card { padding-inline: 17px; }
  .resource-card h3 { font-size: 18px; }
  .card-bottom { font-size: 11px; }
  .detail-layout { grid-template-columns: minmax(0, 1fr) 230px; gap: 22px; }
  .record-stats > div { padding-inline: 24px; }
  .record-stats dd { font-size: 16px; }
  .record-stats .transcript-id { font-size: 13px; }
  .sort-button { font-size: 11px; }
  table { font-size: 12px; }
  .transcript-cell { font-size: 11px; }
  .catalog-meta p { font-size: 11px; }
}
@media (max-width: 850px) {
  .wb-grid { grid-template-columns: minmax(0, 1fr); }
  .page-width, .header-inner, .primary-nav, .footer-inner, .footer-bottom { width: calc(100% - 40px); }
  .header-inner { min-height: 75px; gap: 20px; }
  .header-caption { font-size: 13px; padding-left: 20px; }
  .primary-nav a { padding-inline: 17px; font-size: 13px; }
  .primary-nav a:first-child { margin-left: -17px; }
  .hero h1 { font-size: 32px; }
  .hero-subtitle { font-size: 20px; }
  .hero-description { line-height: 1.75; font-size: 12px; }
  .hero-stats div { padding-inline: 13px; }
  .hero-stats strong { font-size: 21px; }
  .hero-stats span { font-size: 9px; }
  .button-row { gap: 15px; }
  .button-row .button, .text-link { font-size: 12px; }
  .hero-figure figcaption { font-size: 11px; }
  .section-heading { gap: 25px; }
  .section-heading > p { max-width: 290px; font-size: 12px; }
  h2 { font-size: 23px; }
  .resource-grid { gap: 13px; }
  .resource-card p { font-size: 13px; min-height: 46px; }
  .card-bottom { flex-direction: column; gap: 3px; }
  .steps-grid { gap: 23px; }
  .step-card p { font-size: 12px; }
  .step-card h3 { font-size: 15px; }
  .feature-grid { gap: 23px; }
  .guidance-panel { grid-template-columns: .8fr 1.8fr; padding: 22px; gap: 25px; }
  .content-panel { padding: 22px; }
  .detail-layout { grid-template-columns: minmax(0, 1fr) 210px; gap: 20px; }
  .sidebar-panel, .sidebar-note { padding: 18px; }
  .section-nav a { font-size: 12px; }
  .record-stats > div { padding-inline: 20px; }
  .record-stats dt { font-size: 11px; }
  .catalog-toolbar { padding-inline: 18px; gap: 17px; }
  .catalog-meta { padding-inline: 18px; }
  .catalog-meta > p:last-child { display: none; }
  .catalog-panel th:first-child, .catalog-panel td:first-child { padding-left: 18px; }
  .sort-button { font-size: 10px; }
  .badge { font-size: 11px; }
  .about-layout { grid-template-columns: 1.6fr 1fr; gap: 22px; }
  .contact-panel { padding: 22px; }
  .contact-email { font-size: 13px; }
}
@media (max-width: 650px) {
  .header-inner { min-height: 82px; flex-direction: column; align-items: flex-start; justify-content: center; gap: 5px; padding-block: 14px; }
  .brand { font-size: 26px; }
  .header-caption { border: 0; padding: 0; font-size: 12px; }
  .primary-nav { width: 100%; overflow-x: auto; padding-left: 8px; scrollbar-width: thin; }
  .primary-nav a { padding: 11px 12px 9px; font-size: 12px; }
  .primary-nav a:first-child { margin-left: 0; }
  .hero { padding-block: 25px; }
  .hero h1 { font-size: 34px; }
  .hero-subtitle { font-size: 22px; max-width: none; }
  .hero-description { max-width: 1060px; font-size: 14px; line-height: 1.85; }
  .button-row .button, .text-link { font-size: 12px; }
  .hero-stats { margin-top: 20px; padding-top: 16px; }
  .hero-stats div { padding-inline: 22px; }
  .hero-stats strong { font-size: 24px; }
  .hero-stats span { font-size: 10px; }
  .hero-figure img { padding: 16px; }
  .hero-figure figcaption { font-size: 12px; }
  .publication-strip { margin-top: 19px; display: block; padding: 13px 16px; font-size: 12px; }
  .publication-strip > strong { display: block; margin-bottom: 4px; }
  .publication-strip a { white-space: normal; overflow-wrap: anywhere; }
  .section-space { padding-block: 28px; }
  .section-heading { flex-direction: column; align-items: flex-start; gap: 10px; margin-bottom: 19px; }
  .section-heading > p { max-width: none; font-size: 13px; }
  h2 { font-size: 24px; }
  .resource-grid { grid-template-columns: 1fr; gap: 12px; }
  .resource-card { padding: 17px 18px 13px; }
  .resource-card h3 { font-size: 20px; }
  .resource-card p { flex: 1; font-size: 13px; min-height: 0; }
  .card-bottom { flex-direction: row; font-size: 12px; }
  .steps-grid { grid-template-columns: 1fr; gap: 22px; }
  .step-card h3 { font-size: 17px; }
  .step-card p { font-size: 13px; }
  .feature-grid { grid-template-columns: 1fr; gap: 24px; }
  .feature-point p { font-size: 13px; }
  .scientific-figure img, .overview-figure img { padding: 16px; }
  .scientific-figure figcaption { padding: 11px 13px; }
  .allocation-grid { grid-template-columns: 1fr; gap: 19px; }
  .guidance-panel { grid-template-columns: 1fr; gap: 22px; padding: 22px; }
  .guidance-panel ol { font-size: 13px; }
  .footer-inner { flex-wrap: wrap; gap: 12px 18px; }
  .brand-small { font-size: 20px; }
  .footer-inner p { font-size: 11px; }
  .footer-inner > a:last-child { font-size: 12px; }
  .page-heading { padding-top: 23px; padding-bottom: 23px; }
  .page-heading h1 { font-size: 29px; }
  .page-description { font-size: 13px; }
  .breadcrumb { font-size: 12px; margin-bottom: 15px; }
  .catalog-toolbar { align-items: flex-start; flex-direction: column; gap: 13px; padding: 17px; }
  .search-form { width: 100%; }
  .search-form input { font-size: 12px; }
  .search-form .button { padding-inline: 15px; font-size: 12px; }
  .download-catalog { font-size: 12px; min-height: 34px; padding-block: 6px; }
  .catalog-meta { padding: 0 17px 14px; }
  .catalog-meta #rowCount { font-size: 12px; }
  .table-scroll table { min-width: 710px; }
  #catalog[data-kind="crispr"] table { min-width: 530px; }
  .sort-button { font-size: 12px; }
  table { font-size: 13px; }
  .transcript-cell { font-size: 12px; }
  .badge { font-size: 12px; }
  .catalog-footer { flex-wrap: wrap; gap: 14px; padding: 14px 17px; }
  .catalog-footer label { font-size: 11px; gap: 7px; }
  .pagination { margin-left: auto; gap: 4px; }
  .pagination button { min-width: 27px; height: 29px; }
  .pagination-gap { padding: 0 1px; }
  .section-bottom { padding-bottom: 35px; }
  .about-layout { grid-template-columns: 1fr; }
  .content-panel { padding: 21px; }
  .contact-email { font-size: 15px; }
  .detail-title-row { align-items: flex-start; gap: 15px; }
  .detail-title-row h1 { font-size: 31px; }
  .detail-title-row > .button { margin-top: 25px; font-size: 10px; min-height: 34px; padding: 7px 9px; white-space: nowrap; }
  .record-stats { display: grid; grid-template-columns: 1fr 1fr; gap: 20px 17px; margin-top: 21px; padding-block: 18px; }
  .record-stats > div, .record-stats > div:first-child { border: 0; padding: 0; }
  .record-stats dt { font-size: 12px; }
  .record-stats dd { font-size: 18px; }
  .record-stats .transcript-id { font-size: 13px; }
  .detail-layout { grid-template-columns: minmax(0, 1fr); }
  .detail-sidebar { grid-row: 1; position: relative; display: flex; overflow-x: auto; gap: 15px; padding-bottom: 3px; }
  .detail-sidebar > .sidebar-panel:first-child { min-width: 100%; padding: 17px 20px; }
  .detail-sidebar > .sidebar-panel:not(:first-child) { min-width: 270px; }
  .section-nav { grid-template-columns: 1fr 1fr; gap: 0 24px; }
  .section-nav a { font-size: 12px; }
  .database-links { grid-template-columns: 1fr 1fr; gap: 10px; }
  .database-links a { font-size: 12px; }
  .database-links .small-label { font-size: 10px; }
  .sidebar-note { display: none; }
  .panel-heading h2 { font-size: 21px; }
  .content-panel > p { font-size: 13px; }
  .download-panel { padding: 16px; gap: 16px; }
  .download-panel .button { white-space: normal; }
  .download-panel .resource-unavailable { max-width: none; }
  .evidence-figure figcaption { flex-wrap: wrap; gap: 7px; padding: 10px 12px; font-size: 12px; }
  .evidence-figure figcaption > a { font-size: 11px; }
  .evidence-image { padding: 10px; }
  .repository-links { gap: 12px 23px; }
  .not-found h1 { font-size: 28px; }
}
@media (max-width: 380px) {
  .page-width, .header-inner, .footer-inner, .footer-bottom { width: calc(100% - 30px); }
  .primary-nav { padding-left: 3px; }
  .primary-nav a { padding-inline: 10px; font-size: 11px; }
  .hero-subtitle { font-size: 21px; }
  .hero-stats div { padding-inline: 15px; }
  .hero-stats span { font-size: 9px; }
  .footer-inner p { display: none; }
  .pagination button { min-width: 24px; }
  .catalog-footer { padding-inline: 13px; }
  .catalog-footer label { font-size: 10px; }
  .detail-title-row h1 { font-size: 27px; }
  .detail-title-row > .button { font-size: 9px; }
  .content-panel { padding: 18px; }
}
@media (prefers-reduced-motion: reduce) {
  html { scroll-behavior: auto; }
}
@media print {
  .site-header, .site-footer, .detail-sidebar, .button, .breadcrumb, .catalog-toolbar, .catalog-footer { display: none; }
  :root, body { background: #fff; color: #000; }
  .page-width { width: 100%; }
  .detail-layout { display: block; }
  .content-panel { break-inside: avoid; border: 0; padding: 15px 0; }
  .section-space { padding-block: 20px; }
  a { color: inherit; }
  .record-stats { display: flex; }
  body { font-size: 11px; }
  .scientific-figure, .evidence-figure { break-inside: avoid; }
  th { background: #fff; color: #000; }
}